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Cutting Back on Ultra-Processed Foods May Help Ease Depression Symptoms. Recent research has found that reducing UPF intake may help improve symptoms of depression. cafotodigital · E+/Getty A small study found that reducing ultra-processed food (UPF) intake was associated with improvements in depression symptoms. The findings add to previous research linking high UPF consumption with an increased risk of depression. Researchers are investigating how factors such as nutrition, inflammation, metabolic health, and the gut-brain axis may link UPFs with mood. Emerging research has linked high consumption of ultra-processed foods (UPFs) with an increased risk of depression. Now, a small study.